What does a The Metabolic Assessment Profile include?

The Vertical Auto Profile, or VAP, Test is the most comprehensive lipoprotein risk assessment test for Total Cholesterol/Lipid Management. The VAP Test directly measures risk factors associated with heart disease, providing more accurate information than the routine lipid test, which estimates the LDL value. Additionally, the VAP Test directly measures other lipoproteins, which are now widely recognized as risk factors. The VAP Test provides more information with greater accuracy.


• Thyroid function  (TSH, Free T4, Total T4, Free T3, Total T3)

• Adrenal health (including: cortisol & DHEA)

• Insulin resistance & diabetes

• All reproductive hormones (including: estrogen, progesterone, prolactin & testosterone)

• B12 & folate

• Liver function

• Kidney function

• Iron metabolism

• Risk for Ovarian cancer

• Risk for Rheumatoid Arthritis

• Vitamin D levels

• PSA (Prostate Specific Antigen)

Included inflammatory markers:

C-Reactive Protein-hs
High sensitivity C-Reactive Protein (hsCRP) is a nonspecific inflammatory marker produced by the liver in response to inflammatory adipocytokines and macrophages. It is a strong and independent risk marker for primary and secondary CHD events, sudden death, stroke and peripheral vascular disease. Elevation of hsCRP is also associated with insulin resistance and metabolic syndrome.


Lipoprotein-Associated Phospholipase A2 (LpPLA2) is an enzyme responsible for the hydrolysis of oxidized phospholipase on LDL. It is a specific marker for vascular inflammation and is produced in unstable atherosclerotic plaque. Elevated levels indicate a 2 fold increase risk for CVD events and ischemic stroke.

GlycoMark measures I,5 anhydroglucitol (1,5 – AG). It is a nonmetabolized monosaccharide present in small amounts in most foods. I,5 – AG reflects peak glucose levels over 1-2 weeks (short term glucose control). These peaks , not detected by A1C, are associated with the cardiovascular complications of diabetes. 1,5 – AG levels assist in monitoring drug efficacy and treatment alterations including diet and exercise regimens in patients with A1C's at or near goal.

Homocysteine is an amino acid associated with methionine metabolism.  Homocysteinemia is an independent risk factor for primary and secondary CHD events, CHD death, stroke and all causes of mortality. Each increase of 5 umol/L in homocysteine level increases the risk of CHD events by approximately 20%, independent of traditional risk factors.

Gamma-Glutamyl Transferase (GGT) is an enzyme catalyst in the degradation of glutathione, the major antioxidant in the body. GGT is a sensitive proatherogenic, prognostic biomarker for oxidative stress and subclinical atherosclerosis, along with being an independent predictor of metabolic syndrome. Elevated levels are associated with hypertension, insulin resistance, diabetes, obesity, fatty liver and an increase in all causes of mortality and morbidity.

Uric Acid
Uric acid is the degradation product of purine metabolism. Uric acid elevations are associated with gout, hypertension, metabolic syndrome, CVD, CHF, CVA, dementia, preeclampsia, kidney disease, leukemia and oxidative stress. For every 1 mg/dL increase in serum uric acid, there is a 41% excess risk for mortality. Elevated serum uric acid levels in patients with hypertension are associated with a 3-5 fold increased risk of CAD or CVA.

Please call 734-726-0153 to schedule a free consultation and evaluation. At Digestive Health Ann Arbor we are known for providing professional and compassionate care. We strive to guide people towards a comprehensive and holistic healing strategy. Restoring your body to health will restore the quality of your life.